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Observation on the Water Flow of Hadero Lake (Sindh)
Observation on the Water Flow of Hadero Lake (Sindh)
Observation on the Water Flow of Hadero Lake (Sindh)
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Hadero lake has emerged as an important wintering area offer a wide variety of water fowl. 49 species of waterfowl belonging to 6 orders and 12 families have been recorded from the area during the period 1998-2001, which include some rare and threatened species. The status of each bird species has also been recorded. During mid/winter counts of water fowl the highest population of 16864 waterfowl was counted in 1999.
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Other Articles:
| • | Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling |
| Background: There are various methods for predicting human pharmacokinetics. Among these, a whole body physiologically-based pharmacokinetic (WBPBPK) model is useful because it gives a mechanistic description. However, WBPBPK models cannot predict human pharmacokinetics with enough precision. This study was conducted to elucidate the primary reason for poor predictions by WBPBPK models, and to enable better predictions to be made without reliance on complex concepts. Methods: The primary reasons for poor predictions of human pharmacokinetics were investigated using a generic WBPBPK model that incorporated a single adjusting compartment (SAC), a virtual organ compartment with physiological parameters that can be adjusted arbitrarily. The blood flow rate, organ volume, and the steady state tissue-plasma partition coefficient of a SAC were calculated to fit simulated to observed pharmacokinetics in the rat. The adjusted SAC parameters were fixed and scaled up to the human using a newly developed equation. Using the scaled-up SAC parameters, human pharmacokinetics were simulated and each pharmacokinetic parameter was calculated. These simulated parameters were compared to the observed data. Simulations were performed to confirm the relationship between the precision of prediction and the number of tissue compartments, including a SAC. Results: Increasing the number of tissue compartments led to an improvement of the average-fold error (AFE) of total body clearances (CLtot) and half-lives (T1/2) calculated from the simulated human blood concentrations of 14 drugs. The presence of a SAC also improved the AFE values of a ten-organ model from 6.74 to 1.56 in CLtot, and from 4.74 to 1.48 in T1/2. Moreover, the within-2-fold errors were improved in all models; incorporating a SAC gave results from 0 to 79% in CLtot, and from 14 to 93% in T1/2 of the ten-organ model. Conclusions: By using a SAC in this study, we were able to show that poor prediction resulted mainly from such physiological factors as organ blood flow rate and organ volume, which were not satisfactorily accounted for in previous WBPBPK models. The SAC also improved precision in the prediction of human pharmacokinetics. This finding showed that the methodology of our study may be useful for functionally reinforcing a WBPBPK model. | |
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| • | FDA: Director, Division of Applied Pharmacology Research |
| Director, Division of Applied Pharmacology Research, FDA, Silver Spring, MD 20993. Posted on 25 July 2007. | |
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| • | Fingerprint breakthrough hope in US double murder probe |
| (University of Leicester) Technique developed by University of Leicester and Northamptonshire police. | |
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| • | [LETTERS] A Developmental Venous Anomaly Presenting Atypical Findings on Susceptibility-Weighted Imaging |
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| • | maxiaids.com - MaxiAids.com - Products for Independent Living. For blind, low vision, deaf, disabled, handicapped |
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| • | Home | Stereoscopic Microscope |
| Microscopes are the most important instrument in any laboratories, clinics and hospitals. But don’t you know that a microscope can also be used by | |
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Journal of Biological Sciences
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By editor@weddingssitereviews.com - Copyright © 2008 Microsoft. All rights reserved. These XML results may not be used, reproduced or transmitted in any manner or for any purpose other than rendering Live Search results within an RSS aggregator for your personal, non-commercial use. Any other use of these results requires express written permission from Microsoft Corporation. By accessing this web page or using these results in any manner whatsoever, you agree to be bound by the foregoing restrictions. - version: v1.5 build A