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The Schiavo case

(Institut de recherches cliniques de Montreal) In 1990, Theresa Schiavo, an American citizen, had a cardiac arrest that caused irreversible brain damage which led to a persistent vegetative state diagnosis. A few years later, this diagnosis became a source of conflict over the interruption of artificial nutrition. The "Schiavo Case" was widely discussed from a medical, ethical and social standpoint in the United States and elsewhere. An article will be published in the Sept. 23 issue of Neurology.

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Other Articles:

•	*Studies on Fillet Composition of Fresh Water Farmed Labeo rohita* in Relation to Body Size, Collected from Government Fish Seed Hatchery Mian Channu Pakistan**
	The present study was carried out to investigate the fillet composition of fresh water farmed Labeo rohita in relation to body size. For this purpose forty-five specimens ranged in total length from 15.6 to 31.5 cm and in weight from 36.82 to 350.17 g were collected from Government Fish Seed Hatchery Mian Channu during November 2001. After the removal of head, scales, fins and viscera, the remaining trunk (processing yield) was cut into fore, mid and hind fillets. Each fillet was dried and powdered for the analysis of dry mass, water mass, ash content, organic content (all on percentage basis). There was a good correlation between water content (%) and other constituents (% ash, % organic mass) of the processing yield. Body mass and total length significantly affect the processing yield and nutrient constituents. Equations were developed to describe the relationships between body constituents and body mass and length. ANOVA was applied to assess the difference among the body composition parameters. Significant differences were found in these fillets, which indicates the quantitative and qualitative nature of fillets for nutritive purposes.
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•	Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation
	Background: One of the greatest challenges facing biomedical research is the integration and sharing of vast amounts of information, not only for individual researchers, but also for the community at large. Agent Based Modeling (ABM) can provide a means of addressing this challenge via a unifying translational architecture for dynamic knowledge representation. This paper presents a series of linked ABMs representing multiple levels of biological organization. They are intended to translate the knowledge derived from in vitro models of acute inflammation to clinically relevant phenomenon such as multiple organ failure.Results and DiscussionABM development followed a sequence starting with relatively direct translation from in-vitro derived rules into a cell-as-agent level ABM, leading on to concatenated ABMs into multi-tissue models, eventually resulting in topologically linked aggregate multi-tissue ABMs modeling organ-organ crosstalk. As an underlying design principle organs were considered to be functionally composed of an epithelial surface, which determined organ integrity, and an endothelial/blood interface, representing the reaction surface for the initiation and propagation of inflammation. The development of the epithelial ABM derived from an in-vitro model of gut epithelial permeability is described. Next, the epithelial ABM was concatenated with the endothelial/inflammatory cell ABM to produce an organ model of the gut. This model was validated against in-vivo models of the inflammatory response of the gut to ischemia. Finally, the gut ABM was linked to a similarly constructed pulmonary ABM to simulate the gut-pulmonary axis in the pathogenesis of multiple organ failure. The behavior of this model was validated against in-vivo and clinical observations on the cross-talk between these two organ systems Conclusion: A series of ABMs are presented extending from the level of intracellular mechanism to clinically observed behavior in the intensive care setting. The ABMs all utilize cell-level agents that encapsulate specific mechanistic knowledge extracted from in vitro experiments. The execution of the ABMs results in a dynamic representation of the multi-scale conceptual models derived from those experiments. These models represent a qualitative means of integrating basic scientific information on acute inflammation in a multi-scale, modular architecture as a means of conceptual model verification that can potentially be used to concatenate, communicate and advance community-wide knowledge.
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•	RFT group: Quality Engineer
	Quality Engineer, RFT group, Dublin, Ireland. Posted on 25 July 2007.
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•	[BOOK REVIEWS] Pediatric Neuropathology: A Text-Atlas

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•	Stereo Microscope Penny images
	See how large a penny looks at various magnifications with a microscope. Stereo Microscope Magnification. Field of View or Field Diameter
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EurekAlert! - Policy and Ethics
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