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Conservation International gets support from Dreamworks Animation to protect giant pandas
Conservation International gets support from Dreamworks Animation to protect giant pandas
Conservation International gets support from Dreamworks Animation to protect giant pandas
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(Conservation International) Conservation International has received a contribution from DreamWorks Animation SKG Inc. in support of its conservation efforts to protect the Endangered giant panda. CI will use the $1 million contribution to jump-start its Giant Panda Survival Plan, a bold blueprint for panda conservation in China. CI, along with the Chinese government and its local community partners, aims to ensure the survival of the giant panda in its natural habitat.
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Other Articles:
| • | Isolation, Characterization and Growth Response of Pesticides Degrading Bacteria |
| In Pakistan, insecticides are widely used in agriculture. Despite their biodegradable nature, some are highly toxic and their residues are found in the environment. Moreover, its removal from wastewater generated during manufacture becomes inevitable. Reports on the mineralization of a spectrum of different insecticides by a single potential strain are scarce. In this study, a bacterial strain was isolated from soil using enrichment technique and identified as Pseudomonas sp. by microscopic examination and biochemical tests. Growth curve experiments showed that Pseudomonas strain was able to grow in nutrient medium containing malathion (35-220 mg L-1), methamidophos (80-320 mg L-1), cartap (60-120 mg L-1) and cypermethrin (40-125 mg L-1) pesticide. However, the optimum concentration which support normal bacterial growth during 24 h was found to be 120 mg L-1 malathion, 160 mg L-1 methamidophos, 80 mg L-1 cartap and 60 mg L-1cypermethrin. When compared with the control test, a significant increased in bacterial population was noted at low concentration of each pesticide, however at high concentration lag phase increased but no zone of inhibition observed. These data indicate that the isolated Pseudomonas strain can be used as a microorganism for the bioremediation of pesticide contaminated soil or water. | |
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| • | Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling |
| Background: There are various methods for predicting human pharmacokinetics. Among these, a whole body physiologically-based pharmacokinetic (WBPBPK) model is useful because it gives a mechanistic description. However, WBPBPK models cannot predict human pharmacokinetics with enough precision. This study was conducted to elucidate the primary reason for poor predictions by WBPBPK models, and to enable better predictions to be made without reliance on complex concepts. Methods: The primary reasons for poor predictions of human pharmacokinetics were investigated using a generic WBPBPK model that incorporated a single adjusting compartment (SAC), a virtual organ compartment with physiological parameters that can be adjusted arbitrarily. The blood flow rate, organ volume, and the steady state tissue-plasma partition coefficient of a SAC were calculated to fit simulated to observed pharmacokinetics in the rat. The adjusted SAC parameters were fixed and scaled up to the human using a newly developed equation. Using the scaled-up SAC parameters, human pharmacokinetics were simulated and each pharmacokinetic parameter was calculated. These simulated parameters were compared to the observed data. Simulations were performed to confirm the relationship between the precision of prediction and the number of tissue compartments, including a SAC. Results: Increasing the number of tissue compartments led to an improvement of the average-fold error (AFE) of total body clearances (CLtot) and half-lives (T1/2) calculated from the simulated human blood concentrations of 14 drugs. The presence of a SAC also improved the AFE values of a ten-organ model from 6.74 to 1.56 in CLtot, and from 4.74 to 1.48 in T1/2. Moreover, the within-2-fold errors were improved in all models; incorporating a SAC gave results from 0 to 79% in CLtot, and from 14 to 93% in T1/2 of the ten-organ model. Conclusion: By using a SAC in this study, we were able to show that poor prediction resulted mainly from such physiological factors as organ blood flow rate and organ volume, which were not satisfactorily accounted for in previous WBPBPK models. The SAC also improved precision in the prediction of human pharmacokinetics. This finding showed that the methodology of our study may be useful for functionally reinforcing a WBPBPK model. | |
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| • | Queen's University Belfast: Research Fellow |
| Research Fellow, Queen's University Belfast, Belfast, United Kingdom. Posted on 25 July 2007. | |
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| • | [LETTERS] Reply: |
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| • | digitalfotoclub.com - Compare digital cameras at Digital Foto Club - Home and portable electronics, appliances, housewares and more |
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| • | Microscope-Stereo |
| Welcome to WordPress. This is your first post. Edit or delete it, then start blogging! | |
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EurekAlert! - Policy and Ethics
By editor@weddingssitereviews.com - Copyright 2008 by the American Association for the Advancement of Science - version: v1.5 build A
By editor@weddingssitereviews.com - Copyright 2008 by the American Association for the Advancement of Science - version: v1.5 build A