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Microscopes are the most important instrument in any laboratories, clinics and hospitals. But don’t you know that a microscope can also be used by
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Other Articles:
| • | Surface Water Suitability for Drinking Purpose in Cholistan Desert |
| The desert dwellers in Cholistan desert use surface water collected in natural depressions or dugout ponds `Tobas` since the groundwater is brackish and not fit for human consumption especially for drinking purpose. The present study was conducted in cholistan desert to evaluate the quality of rainwater harvested in low lying areas or dugout ponds the only source of drinking water for humans as well as their livestock. Water samples were collected from 10 tobas of lesser Cholistan since most of the tobas were dried up due to the drought conditions. These samples were analyzed to quantify different parameters i.e. pH, HT, TDS, Alkalinity, Ca, Mg, Na, K, Fe, Zn, Cd, Cr, Cu, Sr, Ni, Pb, Co, Cl, PO4, SO4, CO3--, HCO3- and NO3 relating the water quality. The results showed that most of the parameters were found within the WHO recommended levels determining the suitability of this water for drinking purpose. However, Chemical Oxygen Demand (COD) concentration was found high indicating undesirable presence of organic matter. Higher concentration of Sr was found demanding future detailed study of drinking water in Cholistan. | |
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| • | Identification of restriction endonuclease with potential ability to cleave the HSV-2 genome: Inherent potential for biosynthetic versus live recombinant microbicides |
| Background: Herpes Simplex virus types 1 and 2 are enveloped viruses with a linear dsDNA genome of ~120?200 kb. Genital infection with HSV-2 has been denoted as a major risk factor for acquisition and transmission of HIV-1. Developing biomedical strategies for HSV-2 prevention is thus a central strategy in reducing global HIV-1 prevalence. This paper details the protocol for the isolation of restriction endunucleases (REases) with potent activity against the HSV-2 genome and models two biomedical interventions for preventing HSV-2.Methods and ResultsUsing the whole genome of HSV-2, 289 REases and the bioinformatics software Webcutter2; we searched for potential recognition sites by way of genome wide palindromics. REase application in HSV-2 biomedical therapy was modeled concomitantly. Of the 289 enzymes analyzed; 77(26.6%) had potential to cleave the HSV-2 genome in > 100 but < 400 sites; 69(23.9%) in > 400 but < 700 sites; and the 9(3.1%) enzymes: BmyI, Bsp1286I, Bst2UI, BstNI, BstOI, EcoRII, HgaI, MvaI, and SduI cleaved in more than 700 sites. But for the 4: PacI, PmeI, SmiI, SwaI that had no sign of activity on HSV-2 genomic DNA, all 130(45%) other enzymes cleaved < 100 times. In silico palindromics has a PPV of 99.5% for in situ REase activity (2) Two models detailing how the REase EcoRII may be applied in developing interventions against HSV-2 are presented: a nanoparticle for microbicide development and a "recombinant lactobacillus" expressing cell wall anchored receptor (truncated nectin-1) for HSV-2 plus EcoRII. Conclusion: Viral genome slicing by way of these bacterially- derived R-M enzymatic peptides may have therapeutic potential in HSV-2 infection; a cofactor for HIV-1 acquisition and transmission. | |
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| • | Computercraft: Microarray Curator |
| Microarray Curator, Computercraft, McLean, VA. Posted on 25 July 2007. | |
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| • | Public health and human rights: The work ahead of us |
| (Johns Hopkins University Bloomberg School of Public Health) On Dec. 5, the Johns Hopkins Bloomberg School of Public Health and the New York Academy of Sciences will host a half-day symposium to mark the 60th Anniversary of the Universal Declaration of Human Rights. The event, "Public Health and Human Rights: The Work Ahead of Us," will evaluate progress in public health and human rights over the last 60 years. | |
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| • | [BOOK REVIEWS] Neuropsychiatric Disorders: An Integrative Approach |
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| • | meade.com - Meade Telescopes, Microscopes, Meade Instruments, Telescopes by Meade |
| astronomers, astronomy, astrophotography, binoculars, comets, constellations, coronado, digital camera binoculars, galaxies, mars the planet, mead, mead telescopes, meade, meade instruments, meade telescopes, microscopes, moons, optics, planets, redfield optics, simmons optics, solar systems, stars, telescopes, weaver optics | |
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